Mr Blackford branded the situation a “shambles” and called for a general election after Liz Truss sacked Mr Kwarteng and parachuted former foreign secretary Jeremy Hunt into Number 11 in his place.
“We’ve really seen the credibility for financial competence, for the financial management of this government really put to bed,” he told the BBC.
“Over the last few years, we’ve gone from Cameron, we’ve had Theresa May, we’ve had Boris Johnson, we’ve now had the shambles of Liz Truss.
“None of these prime ministers have acted in the interests of the people of Scotland and collectively they have got us into this mess. It’s not another Tory prime minister that we need. We need away from Westminster, we need independence.”
Mr Blackford joined Labour leader Sir Keir Starmer’s calls for a general election, saying there had been a “whole series” of “shambolic” Tory governments.
He added: “We want the ability to remove this Tory government.
“But of course, we’ve had a whole series of shambolic Tory governments over the course of the last few years.”