In Ghana’s Group H first match against Portugal, the man with the most caps for the nation connected to a pass from Mohammed Kudus to tie the score.
Prior to the Al Sadd forward tying the score ten minutes later, Ronaldo had given the 2016 European Champions the lead from the penalty spot.
Cameroon, the defending African champions, lost their initial match to the Netherlands, and Senegal, Tunisia, Morocco, and Morocco also failed to score in their opening matches.
Ayew has now netted three goals at the World Cup, making his third appearance on the global stage.
Meanwhile, in a thrilling encounter, Ronaldo, Joao Felix, and Rafael Leao scored for the Portuguese, while Ayew and Osman Bukari netted for Ghana.
Ayew must produce another warrior performance for his country in their second group game at the 2022 FIFA World Cup tournament in Qatar to have a chance to play in the knockout stages of the mundial.
Ghana will next face South Korea, before finishing their group with a clash against Uruguay on December 2.