The US claims that during a combined operation with the Somali government, it killed five al-Shabab fighters in Somalia.
The air strike, according to the US command in Africa (Africom), was carried out in Bacadweyne, a town in central Somalia, roughly 460 kilometers (285 miles) from the capital Mogadishu.
Initial evaluations indicated that five extremists had been killed, but it added that additional inquiries were ongoing. No reports of civilian injuries have been made.
More than 300 al-Shabab extremists were reportedly slain in southern Somalia on Thursday, according to Somali authorities.
It comes as Somali federal troops, backed by the US, clan militia and African Union troops, continue a counter-insurgency against the al-Qaeda affiliate.
This has turned the tide in favour of Somali forces, which have in recent months retaken huge territories that had been held by al-Shabab for years.
Somali President Hassan Sheikh Mohamud has made the fight against al-Shabab his top priority as he bids to end the 15-year insurgency by the group.